Clinicopathological character and prognosis of rectum mucinous adenocarcinomas
10.3760/cma.j.issn.1007-631X.2016.09.016
- VernacularTitle:直肠黏液腺癌临床病理学特征及预后分析
- Author:
Yanming LIN
;
Hongda PAN
;
Yifan PENG
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Prognosis;
Mucinous adenocarcinomas
- From:
Chinese Journal of General Surgery
2016;31(9):747-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate if mucinous subtype has a relevant impact on disease-free survival (DFS) of patients with rectal carcinoma.Methods The clinicopathological data of patients with rectal adenocarcinomas (ring cell carcinoma were excluded)undergoing radical surgery at Beijing Cancer Hospital from Jan 2010 to Jan 2012 were retrospectively studied,survival analysis was done to detect potential prognostic predictors.Results 353 patients with stage Ⅰ-Ⅲ rectal cancer were included in this study,of whom 28 (7.9％) had mucinous histology.The 3-year DFS for patients with a mucinous adenocarcinoma was 50.0％ and 83.4％ for patients with nonmucinous adenocarcinoma (P ＜ 0.001).Mucinous adenocarcinoma was associated with advanced pathologic T (T3/4,100％ vs 52.3％,P ＜0.001) and N stage (N1/2,64.3％ vs.32.6％,P =0.001).More patients were diagnosed under 40 years in mucinous adenocarcinoma group (21.4％ vs.5.5％,P =0.005).Conclusions Patients with mucinous adenocarcinoma more often present at a younger age,mucinous adenocarcinomas are associated with more advanced tumor stages,and should be regarded as a dismal prognostic factor for the survival of patients with rectal cancer.
