The status and progress of studies on monocyte chemoattractant protein-1 in retinal diseases
10.3760/cma.j.issn.1005-1015.2016.05.032
- VernacularTitle:单核细胞趋化蛋白在视网膜疾病中的表达和作用
- Author:
Lei WANG
;
Xiaomin ZHANG
;
Xiaorong LI
- Publication Type:Journal Article
- Keywords:
Retina diseases/etiology;
Chemokine CCL2;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2016;32(5):564-566
- CountryChina
- Language:Chinese
-
Abstract:
Monocyte chemoattractant protein-1 (MCP-1) is a cytokine which belongs to the CC chemokine family.Retinal pigment epithelium (RPE) cells,photoreceptors and microglial cells in the retina can secrete MCP-1.Physiological level of MCP-1 is important for preserving morphology of RPE and glial cells,as well as retinal function and gross morphology.MCP-1 is likely released from Müller glia and the RPE cells when retina under stress,and attracts microglia/macrophages to the sites of retinal damage,activates the microglia to ingest cell debris.MCP-1 has been found upregulated in the intraocular fluid of retina in patients and animal models with retinal detachment,posterior uveitis and age-related macular degeneration.The expression of MCP-1 may be response to retinal inflammation.Therefore,it is tempting to speculate that pharmacological targeting of MCP-1 may be a safe and viable strategy in treatment of retinal disease.
