The status of studies on the treatment and prognosis estimation in idiopathic macular hole

VernacularTitle:特发性黄斑裂孔治疗及预后判断研究现状
Author: Qing BAO ; Yiqiao XING
Publication Type:Journal Article
Keywords: Retinal perforations/surgery; Vitreoretinal surgery; Retinal perforations/drug therapy; Tomography,optical coherence; Review
From: Chinese Journal of Ocular Fundus Diseases 2016;32(5):549-553
CountryChina
Language:Chinese
Abstract: Idiopathic macular hole (IMH) refers to full thickness defects of retina in macular area with no clear reasons.The management of IMH includes vitrectomy combined with internal limiting membrane (ILM) peeling and pharmacological vitreolysis.But ILM peeling may damage the inner retina;novel techniques,such as inverted ILM flap technique and foveola non-peeling ILM surgery,autologous ILM transplantation had made the method of ILM peeling more diversified with less damage.Pharmacological vitreolysis targeting fibronectin and laminin is considered to work in a two-step mechanism,involving both vitreoretinal separation and vitreous liquefaction.Furthermore,IMH judgment and prognosis indicators like ellipsoid zone,macular hole index,hole formation factor,diameter hole index and tractional hole index based on spectral domain optical coherence tomography enriched the assessment of macular hole diameter,depth and shape.How to make full use of new interventions to reduce the incidence of macular hole and obtain a better visual acuity with closed holes is an important direction for future research.