Update on anti-inflammation mechanism of ketogenic diet
10.3760/cma.j.issn.1673-4408.2016.10.011
- VernacularTitle:生酮饮食抑制炎症反应机制的研究进展
- Author:
Jiaying FENG
- Publication Type:Journal Article
- Keywords:
Ketogenic diet;
Inflammation;
Nervous system
- From:
International Journal of Pediatrics
2016;43(10):784-787
- CountryChina
- Language:Chinese
-
Abstract:
The ketogenic diet (KD) is an effective treatment for refractory epilepsy,including some inflammation-induced epileptic encephalopathies,and the mechanism of it is complicated.KD,through multiple targets,plays the role to inhibit pathogens,control inflammation and regulate immune function.In experiments,KD provides an anti-inflammatory effect in some rat models of fever.It has been shown that,KD decreases peripheral edema,attenuates thermal nociception and reduce arachidomic acid level in circulation.KD blocks Nod-like receptor protein 3 (NLRP3),nuclear factor-kappa B (NF-KB),oxygen free radicals,and improves Peroxisome proliferator-actived Receptor(PPAR) γlevel,to reach the effect of anti-inflammatory.This review focuses on ketogenic diet anti-inflammatory mechanism and the recent advances in clinical application.
