Effects of Compound Glycyrrhizin on Serum VEGF of Patients with Alopecia Areata

VernacularTitle:复方甘草酸苷对斑秃患者血清中血管内皮生长因子的影响Δ
Author: Ling LI ; Wei WANG ; Yi CHENG ; Caixia HU ; Mingyuan REN ; Guoqiang ZHANG
Publication Type:Journal Article
Keywords: Alopecia areata; Compound glycyrrhizin; VEGF
From: China Pharmacy 2015;(29):4102-4103
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To observe the effect of Compound glycyrrhizin on serum VEGF of patients with alopecia areata. METHODS:36 alopecia areata patients were selected as trial group and treated with Compound glycyrrhizin(50 mg/time,3 times/d) for 3 months. Double-antibody sandwich ELISA method was adopted to determine the content of VEGF in serum before and after treatment. 36 healthy volunteers were included in control group,and serum content of VEGF in control group was compared with trial group. RESULTS:Compared with control group,the serum content of VEGF was lower in trial group,with statistical signifi-cance(t=5.863,P<0.05). After treatment,the serum VEGF levels of trial group increased,with statistical significance(t=4.351, P<0.05);there was no statistical significance in VEGF levels between trial group and control group after treatment(t=1.678,P>0.05). CONCLUSIONS:Compound glycyrrhizin can cure alopecia areata through increasing serum level of VEGF.