Effect of Thymosinα1 Combined with Chemotherapy on Immune Function in Patients with Advanced Gastric Cancer and Quality of Life
10.6039/j.issn.1001-0408.2015.29.29
- VernacularTitle:胸腺肽α1联合化疗对晚期胃癌患者免疫功能与生存质量的影响
- Author:
Sheng TIAN
;
Xiaoping ZOU
- Publication Type:Journal Article
- Keywords:
Thymosinα1;
Chemotherapy;
Gastric cancer;
Immune function;
Quality of life
- From:
China Pharmacy
2015;(29):4115-4117
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of thymosin α1 combined with chemotherapy on immune function in patients with advanced gastric cancer and quality of life. METHODS:90 patients with advanced gastric cancer were randomly divided into observation group and control group with 45 cases in each group. Control group was treated with FOLFOX4 chemotherapy plan(so-dium oxaliplatin+calcium folinate+fluorouracil),and observation group was additionally treated with thymosin α1 1.5 mg subcutane-ously,once a day,on the basis of control group. A treatment course lasted for 3 weeks,and both received 3 courses of treatment. The immune function and quality of life were evaluated in 2 groups. RESULTS:The effective rate of observation group was 57.8%,and that of control group was 53.3%;there was no significant difference between 2 groups (P>0.05). The incidence of leukopenia in observation group was 24.4%,which was significantly lower than control group (55.6%),with statistical signifi-cance(P<0.05). There was no statistical significance in CD4+,CD8+ and NK score between 2 groups before chemotherapy(P>0.05). After treatment,above index of observation were all higher than those of control group,with statistical significance (P<0.05). The total health QLQ-C30 EORTC score in observation group was higher than in control group after chemotherapy,with sta-tistical significance(P<0.05). CONCLUSIONS:Thymosin α1 combined with chemotherapy can significantly improve the immune function and quality of life.
