Efficacy Observation of Zoledronic Acid in the Treatment of Acute Pain of Vertebral Fractures
10.6039/j.issn.1001-0408.2015.29.39
- VernacularTitle:唑来膦酸用于急性椎体骨折性疼痛的疗效观察
- Author:
Jing WANG
;
Lingjie XIA
;
Rong TAO
;
Songhe MA
;
Yinghai JIANG
- Publication Type:Journal Article
- Keywords:
Acute vertebral fracture;
Pain;
Zoledronic acid;
Osteoporosis
- From:
China Pharmacy
2015;(29):4143-4145
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy of zoledronic acid in the treatment of acute pain of vertebral compres-sion fractures during different courses. METHODS:207 patients with acute thoracic or (and) lumbar vertebral compression frac-tures were selected and randomly divided into trial group(107 cases)and control group(100 cases). Control group was given calci-um carbonate(1 200 mg/d)diclofenac sodium sustained-released tablet(75 mg/d).Trial group was additionally given zoledronic ac-id 5 mg added into 5%Glucose solution 100 ml,intravenous dripping for 15-30 min,on the basis of control group. RESULTS:Af-ter treatment,VAS score of two group decreased significantly,and trial group the decrease was more significant than control group,with statistical significance (P<0.05),there was no statistical significance in VAS score between course≤one month and one month 0.05);after 4d treatment,there was statistical significance in VAS score between course≤one month and one month 0.05);after one week,there was statistical significance in VAS score between one month 2 months (P<0.05).CONCLUSIONS:Zoledronic acid may partly alleviate the pain of acute vertebral fractures,the analgesic effect is more clear in early stage.
