Pharmaceutical Practice for a Patient with 5-Fluorouracil Chemotherapy-induced Diarrhea and Neutropenia Associated with Fever
10.6039/j.issn.1001-0408.2015.29.47
- VernacularTitle:5-氟尿嘧啶致中性粒细胞减少伴发热及化疗相关性腹泻的药学监护
- Author:
Zhiying YU
;
Lin HUANG
;
Qun GU
;
Wanyu FENG
- Publication Type:Journal Article
- Keywords:
5-Fluorouracil;
Chemotherapy-induced diarrhea;
Neutropenia associated with fever;
Pharmaceutical practice
- From:
China Pharmacy
2015;(29):4163-4165
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the way to provide suitable pharmacecaical care for antineophastic drug-induced ADR by clinical pharmacists. METHODS:For one case of 5-FU chemotherapy-induced neutropenia associated with fever and diarrhea, clinical pharmacists provided advices on antibacterial treatment,including imipenem/cilastatin 0.5 g,q6 h,ivgtt;norvancomycin 0.4 g,q6 h,po;levofloxacin 0.4 g,qd,ivgtt;loperamide with initial dose of 4 mg for anti-diarrheal medication,maintaining at 2 mg,q4 h. RESULTS:After 22 days of appropriate antibacterial and anti-diarrheal treatment,the patient's body temperature and he-mogram returned to normal,diarrhea stopped and β-HCG decreased to 61.58 U/L;then the patient was discharged from hospital. CONCLUSIONS:It is beneficial to optimize chemotherapy plan and ADR disposal,and ensure the safety of the treatment that clini-cal pharmacists assist physicans to optimize therapy plan and provide pharmaceutical care.
