Effects of gentiana scabra bage on expression of hepatic typeⅠ,Ⅱ collagen proteins inParagonimus skrjabini rats with liver fibrosis
10.1016/S1995-7645(14)60188-7
- Author:
Zhaoxia QU
;
Fang LI
;
Chaodong MA
;
Jun LIU
;
Shude LI
;
Wenlin WANG
- Publication Type:Journal Article
- Keywords:
Gentiana scabra bage;
Liver fibrosis;
Paragonimus skrjabini;
Collagen protein Ⅰ;
Collagen protein Ⅱ
- From:Asian Pacific Journal of Tropical Biomedicine
2015;(1):60-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of gentiana scabra bage on the expression of hepatic collagen proteins in Paragonimus skrjabinirats with liver fibrosis.Methods:Immunohistochemical technique was used to observe the changes of content of hepatic type Ⅰ, Ⅱ collagen proteins in Paragonimus skrjabinirats with liver fibrosis before and after the gentiana scabra bage treatmeat. Results:Comparing with the model group, changes of hepatic type Ⅰand type Ⅱ collagen proteins in gentiana scabra bage treated group were significantly weakened.Conclusions:Gentiana scabra bage treatment can reduce the content of hepatic type Ⅱ and typeⅠcollagen protein significantly in Paragonimus skrjabinirats with liver fibrosis, thereby, playing the role against hepatic fibrosis.
