Osmolalities of Commercially Supplied Drugs Used in Anesthesia.
10.4097/kjae.1988.21.6.903
- Author:
Sang Kyi LEE
1
;
Hyun Myung KIM
;
Gab Dong KIM
Author Information
1. Department of Anesthesiology, Chonbuk National University Medical School, Chonju, Chonbuk, Korea.
- Publication Type:Original Article
- Keywords:
Osmolality;
Drugs
- MeSH:
Anesthesia*;
Depression;
Freezing;
Hemolysis;
Osmolar Concentration*;
Water
- From:Korean Journal of Anesthesiology
1988;21(6):903-909
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To investigate the osmolality of commercially supplied drugs used in anesthesia, the authors measured the osmolality of a total of 62 drugs with osmometer using the principle of freezing point depression. The osmolality range of drugs observed was 0-12,478 mOsm/kg water. The drugs of osmolality between 240 and 340 mOsm/kg water were 21(34%). Hypertonic drugs(<240 mOsm/kg water) were 18(29%) indicating two-thirds of the drugs were hypo-or hypertonic. Therefore, it is recommended that extreme hypo-or hypertonic drugs should be administered cautiously especially when they are administered rapidly and massively in order to prevent hemolysis or cell shrinkage.
