SUBACUTE ORAL TOXICITY STUDIES OF BCDMH EFFERVESCENT TABLETS FOR HOS-PITAL SEWAGE

VernacularTitle:医院污水消毒剂溴氯海因泡腾片亚急性经口毒性研究
Author: Juan WANG ; Zheng MA ; Shengxian XIA
Publication Type:Journal Article
Keywords: Hospital sewage; BCDMH; Subacute oral toxicity; Rat
From: Modern Hospital 2015;(4):7-10
CountryChina
Language:Chinese
Abstract: Objective To study subacute oral toxicity of a disinfectant for hospital sewage which contained 1-bromo -3 -chloro -5, 5 -dimethylhydantoin (BCDMH) in order to know about its toxicological safety .Methods Animal test and biochemical examination methods were adopted to evaluate its subacute toxicity .Results During the subacute toxicity test, none of the rats died.At the end of the experiment , urine routine and hematological exami -nation were in the normal ranges .There were no difference compared with the control (p >0.05).But serum alanine aminotransferase in both sexes as well as creatinine in male SD rats of the high dose group were increased obviously compared with the control (p <0.05).Mild steatosis and spotty necrosis of liver cells were found in the high dose group during the pathological examination .Conclusion The BCDMH effervescent tablets'no -observed -adverse -effect -level (NOAEL) is 84 mg? kg-1 for male SD rats, and 98 mg? kg-1 for female SD rats.