Advances in Biomarkers of Mild Traumatic Brain Injury in Cerebrospinal Fluid and Blood

VernacularTitle:轻度创伤性脑损伤脑脊液及血液生物标记物研究进展
Author: Wen HUANG ; Shangxun LI ; Xuejian LI ; Hongyun XU
Publication Type:Journal Article
Keywords: forensic pathology; brain injuries; review [publication type]; cerebrospinal fluid; biological m arkers
From: Journal of Forensic Medicine 2015;(6):466-469
CountryChina
Language:Chinese
Abstract: Mild traumatic brain injury (MTBI) is defined as a mild brain trauma resulting in a short loss of consciousness and alteration of mental status. It may also occasionally develop persistent and pro-gressive symptoms. It has been confirmed that MTBI causes changes of anatomic structures in central nervous systemand biomarkers in the body fluid. How ever, there is no sufficient research on relevance among threshold for the brain injury, individual vulnerability and duration of disturbance of conscious-ness. Furthermore, there are no reliable diagnostic methods to establish w hether a blow to the head is sufficient to cause the brain injury. T his review provides references for biomarkers in cerebrospinal fluid and blood associated w ith T B I. It also provides application status and potential prospects for further as-sessment and diagnosis of MTBI.