Research of Tumor Cells Atypia Based on Perspective Imaging of Intense Laser Proton
10.3969/j.issn.1005-202X.2010.02.020
- VernacularTitle:强激光质子束透视成像应用于肿瘤细胞异型性分析的探索研究
- Author:
Guangchang WANG
;
Jianwei ZHANG
;
Zhijian ZHENG
- Publication Type:Journal Article
- Keywords:
intense laser proton beam;
perspective imaging;
tumor cells;
atypia analysis
- From:
Chinese Journal of Medical Physics
2010;27(2):1777-1780
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To research the application of perspective imaging of intense laser proton beam in tumor cells, experi-ments are carried out on an ultra-intense picosecond pulsed laser facility, and the results of perspective imaging on biological samples by high energy proton beam, which is excitated among the interaction of picosecond laser with solid target, is showed. Methods: The laser energy is 12 J, the pulse width of laser is 1.5 ps, the laser focal spot diameter is 15 μm, the coefficientf or the off-axis paraboloid lens is 1.5. The target used in the experiment is made by coating a CH film with 1 μm on the back of the 15 pan-thick Cu. The distance between the proton source (laser spot) and the ant sample is 7 mm (i.e. the object distance), the distance between the sample and the RC film is 63 mm (i.e. the image distance). The detector is a stack of RCF or CR-39 films. Results: The ant is taken as the sample, a high energy proton beam, which is excitated as above on the rear surface of target, makes a 2-dimensional perspective imaging of an ant with high contrast, nanometer spatial resolution and density reso-lution. Conclusions: The result provided possibility of the application of perspective imaging of intense laser proton beam in tumor cells.
