Dosimetric Comparison of Bone Marrow-Sparing Intensity-Modulated Radiotherapy Versus Conventional Intensity-Modulatedr Radiotherapy for Treatment of Cervical Cancer
10.3969/j.issn.1005-202X.2010.01.008
- VernacularTitle:宫颈癌术后盆腔三种放射治疗计划设计方法的剂量学研究
- Author:
Fuli ZHANG
;
Jing CHEN
;
Junmao GAO
;
Jianping CHEN
;
Mingmin ZHENG
- Publication Type:Journal Article
- Keywords:
Cervical neoplasm;
Bone marrow sparing;
Intensity-modulated radiotherapy;
Dosimetry
- From:
Chinese Journal of Medical Physics
2010;27(1):1599-1602
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare bone marrow-sparing intensity-modulated radiotherapy(BMS-IMRT)with conventional (four-field box[3DCRT]and anteroposterior-posteroanterior[CRT])techniques in the treatment of cervical cancer.Methods:For a cohort of 10 patients,BMS-IMRT,3DCRT and CRT planning were designed.The prescribed dose was 45Gy/1.8Gy/25f,95%of the planning target volume received this dose.Doses were computed with a commercially available TPS.Plans were compared according to dose-volume histogram (DVH)analysis in terms of PTV homogeneity and conformity indices(HI and CI)as well as OARs dose and volume parameters.Results:BMS-IMRT had an advantages over 3DCRT and CRT in terms of CI,but inferior to the latter two for HI.BMS-IMRT was superior to 3DCRT in reducing the dose to PBM,small bowel,bladder and rectum.Compared with CRT,BMS-IMRT reduced the volume irradiated to the doses from 30Gy to 40Gy,but increased the volume irradiated to the low doses from 5Gy to 20Gy.In addition,BMS-IMRT reduced the volume of small bowel,bladder,rectum at nearly all dose levels.Conclusion:BMS-IMRT reduced irradiation of PBM compared with 3DCRT technique.Compared with CRT technique,BMS-IMRT reduced the volume of PBM irradiated to high doses.Therefore,for patients with cervical cancer after hysterectomy,BMS-IMRT might reduce acute hematologic toxicity(HT)compared with conventional techniques.
