Effect of lung cancer bone metastasis on serum osteocalcin levels in Chinese population:a meta-analysis of case-control studies
10.11659/jjssx.06E015039
- VernacularTitle:国人肺癌骨转移对血清骨钙素水平影响的 Meta 分析
- Author:
Leyuan ZANG
;
Min MA
;
Jianxin HU
;
Hao QIU
;
Bo HUANG
;
Tongwei CHU
- Publication Type:Journal Article
- Keywords:
osteocalcin;
malignant tumor;
bone metastasis;
meta-analysis
- From:
Journal of Regional Anatomy and Operative Surgery
2016;25(6):442-445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of lung cancer bone metastasis on serum osteocalcin(OC)in Chinese population using me-ta-analysis.Methods Searched the date of PubMed,Web of science,Embase,Cochrane Library,CBM,CNKI,VIP database and Wanfang da-tabase to identify potentially studies which involved the correlation between bone metastasis and serum OC in Chinese patients with lung canc-er.Standardized mean difference(SMD)and 95%CI was used to access the results.Results 8 studies were included.The study showed that the OC in serum would increase significantly when bone metastases happened in Chinese lung cancer patients.SMD(95%)CI was 0.58 [0.15,1.01]and 0.776[0.20,1.34]compared with controls and BM-,respectively.SMD and 95%CI of BM-compared with controls was -0.15[-0.54,0.23],insignificantly.Conclusion Lung cancer bone metastases may raise serum osteocalcin levels in Chinese popu-lation meanwhile this phenomenon will not happen without bone metastasis.
