Efficacy of different dose of Botulinum toxin A in treatment of patients with neurogenic detrusor overactivity

VernacularTitle:不同剂量肉毒素A注射治疗神经源性逼尿肌过度反射患者的有效性
Author: Cai TANG ; Hong SHEN
Publication Type:Journal Article
Keywords: botulinum toxin A; dose; neurogenic detrusor overactivity; incontinence quality of life
From: Journal of Regional Anatomy and Operative Surgery 2016;25(5):350-353
CountryChina
Language:Chinese
Abstract: Objective To research the efficacy of different dose botulinum toxin A in the treatment of patients with neurogenic detrusor overactivity due to spinal cord injury or multiple sclerosis.Methods The datas of 43 patients with neurogenic detrusor overactivity caused by spinal cord injury or multiple sclerosis which accepted treatment in our hostipal were analyzed.And 38 patients were followed up for 12 weeks,of which 20 cases were treated with 200 U botulinum toxin A,and 18 cases received 100 U botulinum toxin A.The average age of 38 patients was 45.3 years old,and the ratio of famale was higher.The incontinence quality of life(I-QOL)changed from baselin after 6 weeks and 12 weeks was recorded.Resluts The final outcomes showed that the efficacy of botulinum toxin A with 200U was better than that with 100 U according to I-QOL score,and the difference was statistical significance(P <0.05).Conclusion The botulinum toxin A has positive effect on neurogenic detrusor overactivity,and the efficacy of 200 U injection is better than that of 100 U.