Oleanolic acid stimulates the expression of bile acids transporters OSTalpha-beta and BSEP in bile duct-ligation rats
10.11659/jjssx.07E015136
- VernacularTitle:齐墩果酸对阻塞性胆汁淤积大鼠胆酸转运蛋白OSTα/β和BSEP的调控作用
- Author:
Jin CHAI
;
Guochun XIANG
;
Xinchan FENG
;
Liangjun ZHANG
;
Ying CHENG
;
Wensheng CHEN
- Publication Type:Journal Article
- Keywords:
cholestasis;
oleanolic acid;
blie acids transporter;
blie duct-ligation
- From:
Journal of Regional Anatomy and Operative Surgery
2016;(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the function and effect of Oleanolic acid to cholestasis on regulating bile acids transporters. Methods A total of 45 rats were divided into 9 groups,5 rats in each group. The Sham group,Bile duct ligation group and Oleanolic acid group were treated with saline or Oleanolic acid for 3 days,7 days and 14 days. Then the liver and tested bile acids transporters in mRNA and protein lev-els were collected. Results The expression of bile acids transporter OSTβ with Oleanolic acid was increased after 3 days. The expression of OSTβ and BESP in Oleanolic acid group after 7 days were increased than those in Sham group. Fourteen days later,the increasing tendency of OSTα,OSTβ and BSEP were sensiable. Conclusion Oleanolic acid can stimulates the expression of bile acids transporters OSTalpha-beta and BSEP in bile duct-ligation rats.
