Effect of low-dose ultrasound-mediated microbubble on the concentration of cefuroxime in rat prostate
10.11659/jjssx.02E015004
- VernacularTitle:低频超声联合造影剂微泡对前列腺组织中头孢呋辛浓度的影响
- Author:
Yonggang SHANG
;
Guangwei HAN
;
Xiaoxiao DONG
;
Dong CUI
;
Chengcheng LIU
;
Shanhong YI
- Publication Type:Journal Article
- Keywords:
chronic prostatitis;
microbubbles;
ultrasonic irradiation;
cefuroxime
- From:
Journal of Regional Anatomy and Operative Surgery
2015;24(6):602-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of ultrasound-mediated microbubble on the concentration of cefuroxime in rat prostate. Methods Twenty male SD rats were randomly divided into the experimental group ( ultrasound-mediated microbubble+cefuroxime group) and the control group ( cefuroxime group) . The experimental group was given cefuroxime and microbubble via the tail vein, and then the prostates were exposed to ultrasonic irradiation for five minutes. The control group was given cefuroxime and the same amount of normal salin via the tail vein, and then given sham ultrasonic irradiation for five minutes. After the prostate was taken, cefuroxime concentration in pros-tate was measured by high performance liquid chromatograph. Results Concentration of cefuroxime in the experimental and the control group were (16. 274 ± 9. 515) μg/mg and (8. 336 ± 6. 743) μg/mg respectively. Compared to the control group, the concentration of cefuroxime was significant higher in the experimental group, and the difference is statistically significant (P <0. 05). Conclusion Low-dose ultra-sound-mediated microbubble can significantly improve the permeability of rat prostate tissue, thereby enhancing the drug concentration in prostate tissue.
