Effects of dexmedetomidine on oxidative stress response after operation in patients with acute craniocerebral trauma
10.11659/jjssx.09E014029
- VernacularTitle:右美托咪定对急性颅脑损伤术后氧化应激的影响
- Author:
Qinghua DENG
;
Jianqiang DAI
;
Xinwen WU
;
Jianyu LI
- Publication Type:Journal Article
- Keywords:
dexmedetomidine;
craniocerebral trauma;
oxidative stress
- From:
Journal of Regional Anatomy and Operative Surgery
2015;(2):198-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of dexmedetomidine on oxidative stress response after operation in patients with acute craniocerebral trauma. Methods Sixty patients who underwent intracranial hematoma and decompressive craniectomy within 24 h after acute craniocerebral trauma,were randomly divided into midazolam group and dexmedetomidine group(n=30). All patients were maintained seda-tion for 12 h after operation. Mean arterial blood pressure (MAP),heart rate (HR),blood glucose,S-100B protein (S-100B),malond-ia1ehyde(MDA) and superoxide dismutase (SOD) were recorded at the end of operation(T0),3 h(T1),6 h(T2),12 h(T3) after opera-tion. Results Postoperative MAP, HR and blood glucose were stability in two groups. MAP, HR and blood glucose of dexmedetomidine group were lower than those of midazolam group(P<0. 05). The serum concentrations of S-100B and MDA gradually reduced,and the serum levels of SOD gradually increased at T1 ~T3 in two groups. Compared with midazolam group, these changes were significantly higher in dexmedetomidine group(P<0. 05). Conclusion Dexmedetomidine can protect the brain by maintaining haemodynamic stability and attenu-ating oxidative stress response after operation in patients with acute craniocerebral trauma.
