Effect of dexmedetomidine combined with parecoxib on postoperative cognitive function in elderly patients re-ceived operation
10.11659/jjssx.05E015060
- VernacularTitle:右旋美托咪定复合帕瑞昔布对老年患者术后认知功能的影响
- Author:
Xinrong WEN
;
Chang LIU
;
Lin CHEN
;
Chengcheng SHEN
- Publication Type:Journal Article
- Keywords:
dexmedetomidine;
parecoxib;
POCD;
systemic inflammatory response syndrome
- From:
Journal of Regional Anatomy and Operative Surgery
2015;24(6):612-615
- CountryChina
- Language:Chinese
-
Abstract:
patients received thoracic surgery. Methods Fifty patients underwent radical resection of pulmonary carcinoma were divided into DP group ( dexmedetomidine infusion by micro pumo and parecoxib 40 mg through intravenous injection) and DN group ( dexmedetomidine infusion by micro pumo and nomal saline 5mL through intravenous injection). The time for spontaneous breath,eye opening and extubation after the oper-ation were recorded. The mimi-mental state examination ( MMSE) was used to assess the cognitive function. The concentration of protein S100β and IL-6,TNF-α were determined at 1 d before operation and 1 h,24 h after the operation. Results The difference of time for spon-taneous breath,eye opening,extubation and preoperative values of MMSE between two groups were not statistically significant(P>0. 05). MMSE scores at 1 d,3 d and 5 d after operation in group DN were lower than those in group DP (P<0. 05). The values of S100β、IL-6、TNF-α at 1 h and 24 h after operation in group DN were higher than that in group DP (P< 0. 05). Conclusion Dexmedetomidine com-bined with parecoxib can decrease the incidence of postoperative cognitive dysfunction in elderly patients underwent thoracic surgery,and the mechanism of which may be related to the downregulation of serum inflammatory factors.
