Clinical study on intra-articular injection of tranexamic acid to reduce blood loss in total knee replacement

VernacularTitle:关节内注射氨甲环酸减少全膝关节置换术后失血的临床分析
Author: Wei PENG
Publication Type:Journal Article
Keywords: inra-articular injection; blood transfusion; tranexamic acid; blood loss; total knee replacement
From: Journal of Regional Anatomy and Operative Surgery 2014;(5):513-515
CountryChina
Language:Chinese
Abstract: Objective To examine the influence of inra-articular injection of tranexamic acid on blood loss after total knee replacement. Methods 50 patients with unilateral primary total knee replacement were enrolled and they were randomly divided into two groups:the stud-y group (n=25 cases),which were given intra-articular injection of tranexamic acid (1 000 mg) and drain clamping for 2 hour posteratively, and the control group ( n=25 cases) ,which were given physiologic saline. The blood loss,postoperative volume of drainage,hemoglobin lev-el,hematocrit,blood transfusion cases,D-dimer level and deep venous tromboemblic ( DVT) events were recorded. Results Postoperative volume of drainage,blood transfusion cases and D-dimer level were lower in the study group (P<0. 05). Hemoglobin level and hematocrit were higher in the study group (P<0. 05). No DVT ocurred in the two groups. Conclusion Intra-articular injection of tranexamic acid with 2 hours of drain-clamping is effective for reducing postoperative blood loss in total knee replacement, and there is noincrease of deep venous tromboemblic.