Effect of dexmedetomidine combined with ropivacaine in brachial plexus block on serum bFGF of fracture pa-tients
10.11659/jjssx.05E015057
- VernacularTitle:右美托咪定复合臂丛神经阻滞对骨折患者血清bFGF的影响
- Author:
Yixing GU
;
Jing GAO
;
Lin CHEN
;
Chang LIU
- Publication Type:Journal Article
- Keywords:
brachial plexus block;
fracture;
dexmedetomidine;
basic fibroblast growth factor
- From:
Journal of Regional Anatomy and Operative Surgery
2015;24(6):660-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dexmedetomidine ( Dex) combined with ropivacaine in brachial plexus block ( BPB) on serum basic fibroblast growth factor ( bFGF) levels of upper limb fracture patients in the perioperative period. Methods 80 patients ( ASA gradeⅠ~Ⅱ) scheduled for selective upper extremity surgery were randomly divided into the dexmedetomidine combined with ropiva-caine group ( RD group) and the ropivacaine group ( R group) with 40 patients in each group. BPB was performed at the point of 2 cm below coracoid directed by nerve stimulator. Ropivacaine (200 mg) was diluted into 40 mL in group R and ropivacaine (200 mg) +1 μg/kg dexmedetomidine were diluted into 40 mL in group RD. Drew 5 mL blood at T0~T4 points respectively,and serum bFGF concentration were determined. Results Compared with group R,MAP and HR at T1~T3 points were significantly lower in group RD (P<0. 05). SpO2 in the two groups at each point had no statistical significance (P>0. 05). Compared with T0 points,bFGF concentration were increased in two groups at T1~T4 points (P<0. 05),and it was higher in group RD compared with group R (P<0. 05). Conclusion Dex combined bra-chial plexus block promote the secretion of bFGF more than simple brachial plexus block,which is conducive to fracture healing after opera-tion,but it should be cautious to apply for patients with bradyarrhythmia.
