Changes and clinical significance of serum thyroid hormone and TNF-αin severe patients
10.11659/jjssx.09E014021
- VernacularTitle:危重患者血清中TNF-α和甲状腺激素水平的变化及临床意义
- Author:
Gangyin XIE
;
Qiang LI
;
Lin YU
- Publication Type:Journal Article
- Keywords:
severe patients;
TNF-α;
thyroid hormone
- From:
Journal of Regional Anatomy and Operative Surgery
2015;(2):146-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of thyroid hormone and TNF-α in severe patients which occurring under critical illness and to explore the interrelation of these endocrine factors in order to direct clinical therapy. Methods Serum thyroid hormone and TNF-αin 102 severe patients and 80 healthy volunteers were detected by radioimmunoassay and enzymoimmunoassay. The results were analyzed and compared with normal subjects,groups of different prognosis,MODS group and no MODS group. Results TT3,FT4,FT3 levels in severe pa-tients were lower than that in normal subjects(P <0. 01),By contrast,TNF-α level were significantly higher than that of control group (P<0. 01). As the situation became worse,the above changes were more obvious in severe patients as compared with normal subjects. For TT3 and TNF-α level,the differences in the early stages of the disease (3 ~7rd) in the survival group and death group were significant (P<0. 05). Compared with non-MODS group,TT3,FT4,FT3 and TNF-α changed significantly in MODS group(P<0. 05). Conclusion TNF-α and thyroid hormone levels play important roles in the severe patients. The changes of TNF-αand thyroid hormone levels can be used for severe patients prediction and treatment.
