Autologous bone-marrow stem-cell transplantation for nonunion of tibia fracture

VernacularTitle:自体骨髓干细胞移植治疗胫骨骨折骨不连
Author: Yulong WANG ; Minggui WANG ; Xiaobing HE ; Hai WANG ; Ruiqiang RAO ; Yanhui JI
Publication Type:Journal Article
Keywords: tibia fracture; nonunion; marrow mesenchymal stem cells; transplantation
From:Journal of Regional Anatomy and Operative Surgery 2014;(2):131-134
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of the percutaneous autologous bone marrow stem cell transplantation for the treatment of nonunion of tibial fracture. Methods From 2007 to 2011,the data of 11 patients with tibial nonunion who received autologous bone marrow stem cell transplantation was analyzed retrospectively. Taking bone marrow,examine,isolation,cultivation and expansion marrow mesenchymal stem cells( MSCs) ,and then marrow needle was inserted into the site of the nonunion under the X-ray,the MSCs were injected into the site of nonunion. Compression bandage was applied after operation. X-rays following-up were reviewed. Results All 11 patients were followed up from 4~27 months,with average of 13 months,X-ray showed:fracture healed well,no adverse events happen. Conclusion Satisfactory out-come can be obtained by percutaneous autologous bone marrow stem cell transplantation in treatment of tibial nonunion. Clinical application value is high,especially to patients who had suffered from severe skin and soft tissue injury with keloids healed.