Gastroprotective Effects of Ascaridole on Gastric Ulcer in Rats
10.3969/j.issn.1674-6384.2012.01.009
- Author:
Yonghong ZHU
;
Xinxin LI
;
Hongmei MO
;
Lihua ZHANG
;
Lanlan ZHANG
;
Shuiping ZHOU
;
Xiaohui MA
;
Boli ZHANG
- Publication Type:Journal Article
- Keywords:
ascaridole;
Aspirin;
chronic gastric ulcer;
gastroprotective effect;
pylorus ligation
- From:
Chinese Herbal Medicines
2012;04(1):58-62
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the gastroprotective activity of ascaridole.MethodsThe gastroprotective effect of ascaridole was evaluated on ulcer healing in rats with acetic acid-induced chronic gastric ulcer,pylorus ligation- and Aspirininduced gastric ulcer.Ascaridole was ig administered with the dosages of 10 and 20 mg/kg once daily for 7 d.Results Ascaridole showed the significant anti-ulcer effects.In acetic acid-induced gastric ulcer rats,the ulcer areas after 10 and 20 mg/kg of ascaridole treatment were (65.1 ± 20.0) and (50.6 ± 11.0) mm2,respectively,which were significant lower (P ＜ 0.01) than that of the control group [(116.7 ± 35.8) mm2].For pylorus ligation model,ascaridole showed a gastric ulcer healing effect in a dose-dependent manner.Ascaridole at the dose of 20 mg/kg showed 50％ ulcer protection and had a significant (P ＜ 0.05) gastroprotective activity since it decreased the total acidity and pepsin activity.Compared to the control group,the two dosages of ascaridole showed the significant reduction (P ＜ 0.05) in the ulcer index on Aspirin-induced ulcer.ConclusionThis study provides evidence that ascaridole shows potential efficacy on the healing of gastric ulcers induced by acetic acid,Aspirin,and pylorus ligation.
