Triterpene Glycosides from Sea Cucumber Holothuria scabra with Cytotoxic Activity
10.3969/j.issn.1674-6384.2012.03.002
- Author:
Hua HAN
;
Ling LI
;
Yanghua YI
;
Xiaohua WANG
;
Minxiang PAN
- Publication Type:Journal Article
- Keywords:
cytotoxicity;
24-dehydroechinoside A;
fuscocineroside C;
Holothuria scabra;
scabraside D;
triterpene glycoside
- From:
Chinese Herbal Medicines
2012;04(3):183-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the new triterpene glycosides from sea cucumber Holothuria scabra with cytotoxic activity.Methods Triterpene glycosides from H.scabra were separated and purified by chromatography on DA-101,silica gel,and reversed-phase silica gel column,as well as RP-HPLC.Their structures were elucidated on the basis of spectral data and chemical evidence.Results Three triterpene glycosides were identified as scabraside D (1),fuscocineroside C (2),and 24-dehydroechinoside A (3).Their inhibition on P-388,A549,MKN-28,HCT116,and MCF-7 cells were significant.Conclusion Scabraside D (1) is a new triterpene glycoside,and compounds 2 and 3 are isolated from H.scabra for the first time.The glycosides 1-3 show the in vitro cytotoxicity against five human tumor cell lines in comparison to 10-hydroxycamptothecin.
