Toxicological Assessment of Trans-resveratrol
10.3969/j.issn.1674-6384.2010.01.003
- Author:
Jianguo ZENG
;
Yixiu HU
;
Xiangqian ZHANG
- Publication Type:Journal Article
- Keywords:
toxicity;
toxicological assessment;
trans-resveratrol
- From:
Chinese Herbal Medicines
2010;2(1):30-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate toxicity and safety of trans-resveratrol (t-RSV). Methods For assays of acute toxicity,genetic toxicity, and sub-chronic toxicity, Ames test, mice bone marrow erythrocyte micronucleus, and mice sperm abnormality were performed. Results In the acute oral toxicity tests, maximum tolerable dose (15 g/kg) in male and female Kunming mice showed no toxicological signs. For 90-d feeding of t-RSV at dosage range of 167-500 mg/(kg·d) in both male and female Sprague-Dawley rats, no noticeable toxicological effects were observed.Conclusion T-RSV has no acute toxicity and no genotoxicity, no harmful effects on the human body at the tested dosage range and thus resveratrol is safe for human consumption.
