Regulation of Fengxiaofang on Expression of Gene Gob-5 in Asthmatic Mice
10.3969/j.issn.1674-6384.2010.01.009
- Author:
Genben BAI
;
Yang LIU
;
Youlin LI
;
Xiaoxin MA
;
Shi YAN
;
Changzheng FAN
;
Yahong GUO
- Publication Type:Journal Article
- Keywords:
allergic asthma;
Fengxiaofang;
gene Gob-5;
real-time quantitative PCR
- From:
Chinese Herbal Medicines
2010;2(1):68-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the regulation of Fengxiaofang on the expression of gene Gob-5 in ovalbumin-challenged asthmatic mice. Methods The murine model of allergic asthma established by ovaibumin was used. The model mice were treated experimentally with Fengxiaofang and Dexamethasone as a positive control. The quantitive expression of gene Gob-5 in lung of mice was detected by real-time quantitative PCR. Results The expression of gene Gob-5 in lung of mice was down-regulated by Fengxiaofang. In the experiment, there were no significant differences between the one-fold or ten-fold dosage groups and the normal control group. Gene Gob-5 expression in five-fold dosage was significantly lower than that in the normal control group. Conclusion Fengxiaofang has the effect of lowering the expression of gene Gob-5 which maybe related to the potency on asthmatic disease.
