Protein Tyrosine Phosphatase 1B Inhibitors from Plantago asiatica
10.3969/j.issn.1674-6384.2011.02.008
- Author:
Long CUI
;
Hyunsun LEE
;
Jongseog AHN
;
Guangxin YUAN
;
Yanan SUN
- Publication Type:Journal Article
- Keywords:
alpinoside;
geniposidic acid;
iridoid glucosides;
Plantago asiatica;
protein tyrosine phosphatase 1B
- From:
Chinese Herbal Medicines
2011;03(2):136-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the active compounds for protein tyrosine phosphatase 1B (PTP1B) from the seeds of Plantago asiatica. Methods Bioassay-guided fractionation resulted in the isolation of iridoid glucosides (1-5) with PTP1B inhibitory activity. Results Five compounds were identified as desacetylhookerioside (1), melittoside (2), geniposidic acid (3), 10-O-acetyl-geniposidic acid (4), and alpinoside (5). Conclusion Isolated compounds 3-5 inhibit PTP1B with IC50 values ranged from (16.3 ± 1.1) to (19.8 ± 1.2) μmol/L.
