Effects of Astragaloside Ⅳ Derivative on Heart Failure in Rats
10.3969/j.issn.1674-6384.2010.01.005
- Author:
Weiting WANG
;
Zhuanyou ZHAO
;
Yingmei HAN
;
Weiren XU
;
Lida TANG
- Publication Type:Journal Article
- Keywords:
astragaloside Ⅳ derivative;
heart failure;
rat
- From:
Chinese Herbal Medicines
2010;2(1):48-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective Astrgaloside Ⅳ derivative (ASId) is one of Astragaloside Ⅳ (ASI) derivatives with higher water-solubility and may have more druggability than ASI. The present study aims at observing the effects of ASId on cardiovascular parameters in chronic heart failure in rats. Methods Using echocardiographic and haemodynamic measurements, the effects of ASId on congestive heart failure (CHF) induced by ligation of the left coronary artery in rats were investigated.ventricle (LV) pressure (dp/dt) in ASId treated groups were significantly increased. Both LV volumes in diastole and in systole were decreased significantly after ASId treatment, accompanied with a trend towards normalization of relative stress. ASId treatment also inhibited compensatory hypertrophy of depressed heart. Conclusion ASId could improve cardiac functions and inhibite compensatory hypertrophy and LV remodelling, which suggests the possibility of ASId as a new therapeutic drug for the treatment of CHF.
