Evaluation of analgesic, cytotoxic and antioxidant activities of Sansevieria roxburghiana Schult. and Schult. f.
10.1016/S2221-1691(12)60303-7
- Author:
Jimuty ROY
;
Mohammad KUDDUS
;
Bilkis BEGUM
;
Choudhury HASAN
- Publication Type:Journal Article
- Keywords:
Sansevieria rxburghiana Schult. and Schult. f.;
Agavaceae;
Analgesic activity;
Antioxidant activity;
Cytotoxic activity
- From:Asian Pacific Journal of Tropical Biomedicine
2012;(z2):723-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the crude methanolic extract of whole plant part of Sansevieria roxburghiana Schult. and Schult. f. (Agavaceae) and the possibility of analgesic, cytotoxic and antioxidant activities. Methods: The analgesic activity was assessed by acetic acid induced writhing test in mice. The cytotoxic activity was evaluated by brine shrimp lethality bioassay while antioxidant effect was measured by 1, 1-diphenyl-2-picrylhydrazyl-hydrate (DPPH) free radical scavenging assay. Results: The ethyl acetate soluble fraction of the crude extract was found to have significant (P<0.001) analgesic activity at the oral dose of 100 mg/kg body weight. In brine shrimp lethality bioassay, the aqueous soluble fraction exhibited maximum toxicity towards the shrimp with LC50 value of 0.735 μg/mL compared to 0.544 μg/mL exhibited by standard vincristine. The crude methanolic extract along with its all partitionates revealed mild to moderate free radical scavenging activity. Conclusions: These primary findings suggest that the extract might possess some chemical constituents that are responsible for analgesic, cytotoxic and antioxidant activities.
