EFFECTS OF SOPHORA FLAVESCENS EXTRACT ON SKIN INFLAMMATIONS OF GUINEA PIGS WITH ECZEMA
10.3969/j.issn.1671-332X.2015.05.008
- VernacularTitle:苦参水提物治疗湿疹豚鼠皮肤炎症的实验研究
- Author:
Yan CHEN
;
Lihua ZHANG
- Publication Type:Journal Article
- Keywords:
Sophora flavescens;
Eczema;
Swelling;
Aqueous extract;
Anti-inflammatory effect
- From:
Modern Hospital
2015;15(5):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibition of Sophora flavescens extract on the degree of inflammatory swelling of guinea pigs'skin with eczema, observe pathological changes and explore the effects of the anti-in-flammatory action, in order to provide experimental basis for clinical treatment.Methods Eczema models of 40 guinea pigs were set up by smearing 2, 4-dinitrochlorobenzene on their napes to cause sensitization and motivating in the inside of their right ears.All guinea pigs were randomly divided into 5 groups equally,including the model com-pared group, positive control group and high, medium, low concentration groups of sophora flavescens.After eczema skin was continuously administered drugs for 14 days, the same part with equal area of the left and right ears was taken and weighed.The difference between the left and right ears was used to evaluate the swelling degree of skin inflammation.The pathological changes were observed by making pathological slices with HE staining with the tissue blocks of right ears.Results Compared with the model group, the swelling degree of skin inflammation was significantly relieved and dermal edema and inflammatory cell infiltrating were significantly improved in the high and medi-um concentration groups of sophora flavescens (p<0.05).Compared with the positive group, the swelling degree of skin inflammation, dermal edema and inflammatory cell infiltrating were significantly alleviated in the high concentra-tion group of sophora flavescens ( p<0.05) .Conclusion Sophora flavescens extract can effectively reduce inflam-matory response of guinea pigs'skin with eczema, having a certain significance for the clinical treatment of eczema.
