THE SIGNIFICANCE OF EXPRESSION OF PTEN AND P27 PROTEINS IN ESOPHAGEAL EPITHELIOSIS AND CARCINOGENESIS
10.3969/j.issn.1671-332X.2015.06.007
- VernacularTitle:PTEN 和 P27蛋白的表达在食管上皮增生和癌变过程中的意义
- Author:
Jiesheng CHENG
;
Mingyao WU
- Publication Type:Journal Article
- Keywords:
PTEN;
P27;
Esophageal epithelium;
Carcinogenesis
- From:
Modern Hospital
2015;(6):17-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of PTEN and P 27 proteins in esophageal epitheliosis and carcinogenesis , and the relation to the development of esophageal carcinoma .Methods PTEN and P27 proteins ex-pression in 60 fresh tissue specimens , including esophageal mucosa above the upper surgical margin , carcinoma in si-tu and mucosa adjacent to tumor , were detected using immunohistochemical method .Results The expression of e-sophageal epithelial cells PTEN and P 27 proteins in normal , hyperplastic and malignant gradually decreased , which showed a similar distribution pattern in esophageal carcinogenesis .Conclusion Malignant transformation expression change of PTEN and P 27 proteins and esophageal mucosa are closely related , and the expression of PTEN and P 27 proteins deletion may be a biological marker useful and esophageal cancer early diagnosis index .
