EVALUATION ON THE EXTERNAL QUALITY ASSESSMENT OF NEWBORN SCREENING FOR INHERITED METABOLIC DISEASE LABORATORY
10.3969/j.issn.1671-332X.2015.06.050
- VernacularTitle:新生儿遗传代谢病筛查室间质量评价结果分析
- Author:
Xiaoying ZHOU
;
Xianhua ZHENG
;
Yongxian ZHOU
- Publication Type:Journal Article
- Keywords:
Neonatal screening;
Phenylalanine;
Thyrotropin;
Phenylketonuria;
Congenital hypothyroidism;
External quality assessment
- From:
Modern Hospital
2015;(6):123-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate our results of external quality assessment (EQA) program of the newborn screening laboratory for 6 years, summarize the problems in the screening measurement and improve the quality of measurement.Methods The phenylalanine (Phe) and thyrotropin (TSH) values in dried blood spot specimens on filter paper distributed by national center were measured by fluorometric method and time -resolved fluorescence im-munoassay ( DELFIA ) respectively.The results sent by national center were analyzed .Results In the 90 specimens of 18 batches, the bias range of Phe and TSH measurement was wide (-62.50%~66.67%and-66.67%~54.31%respectively) and their average values were 8.62%and 10.18% respectively;85 quantitative results of Phe and 84 quantitative results of TSH measurement were in the quality control , accounting for 94.44%and 93.33%respective-ly.The qualitative analysis of 90 Phe and TSH specimens all conformed to the expected results , accounting for 100%.The result of every batch was up to 80%.Conclusion Our neonatal screening laboratory is in control and it is useful to evaluate the measurement competence , find out the problems in the Phe and TSH measurement and re-solve them in time through participated in the national EQA in neonatal screening laboratory , so as to improve the quality of measurement and ensure the accuracy and reliability of results .
