EXPRESSION AND CLINICAL SIGNIFICANCE OF E-cadherin,CerbB-2,p53,Ki-67 IN BREAST CANCER
10.3969/j.issn.1671-332X.2009.08.002
- VernacularTitle:乳腺癌中E-cadherin、CerbB-2、p53、Ki-67的表达及其临床意义
- Author:
Yuqing LI
;
Kaiyong MEI
;
Guangming LU
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Immunohistochemistry;
Histopathology
- From:
Modern Hospital
2009;9(8):2-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between clinical pathology character and expression of E-cadherin，CerbB-2，p53，Ki-67 in breast cancer in order to evaluate its clinical significance.Methods To observe 93 cases of breast cancer.Immunohistochemical methods were used to detect the expression of E-cadherin，CerbB-2，p53，Ki-67.Results We found that the expressions of E-cadherin，CerbB-2，p53，Ki-67 in breast cancer samples were associated to histopathology grade and lymph node metastasis (p<0.05), but the expressions of CerbB-2，p53，Ki-67 were not associated to tumor size and histological type (p>0.05).Compared to other types, it showed low expression of E-cadherin in lobular carcinoma(p<0.05).Conclusion E-cadherin，CerbB-2，p53，Ki-67 can be regarded as molecular indexes of breast cancer, and they can be used to give diagnosis, choose treatment and forecast prognosis in clinical work.
