STUDY ON THE LEVELS OF HOMOCYSTEININ AND NEUTROPHIL GELATINASE ASSOCI-ATED LIPOCALIN IN PATIENTS WITH CHRONIC HEART FAILURE COMBINED INSUFFI-CIENT RENAL FUNCTION
10.3969/j.issn.1671-332X.2015.07.005
- VernacularTitle:慢性心力衰竭并肾功能不全患者外周血同型半胱氨酸和中性粒细胞明胶酶相关脂质运载蛋白的相关性研究
- Author:
Jianping LI
- Publication Type:Journal Article
- Keywords:
chronic heart failure;
insufficient renal function;
neutrophil gelatinase associated lipocalin;
homocysteinin
- From:
Modern Hospital
2015;(7):13-14
- CountryChina
- Language:Chinese
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Abstract:
Objective To investigate the levels of homocysteinin and neutrophil gelatinase associated lipocalin and its rela-tionship in patients with chronic heart failure combined insufficient renal function .Methods 58 patients with chronic heart failure were enrolled in from June 2013 to June 2014 in Beijiao hospital affiliated Southern medical university .Thereinto, according to pa-tient’s condition, 28 patients were chronic heart failure concurrence insufficient renal function, 30 patients were chronic heart failure. Left ventricular ejection fraction were determined by cardiac ultrasound , the levels of serum BNP, Hcy, NGAL and creatine were de-termined.Results Compared with chronic heart failure patients,the levels of Hcy and NGAL were increased in patients with chronic heart failure concurrence insufficient renal function (p<0.05).Correlation analysis showed that the levels of Hcy is positively corre-lated with the levels of NGAL (p<0.05);the levels of Hcy and NGAL were positively correlated with BNP and creatine (p<0.05), but negatively correlated with LVEF (p<0.05), respectively.Conclusion Circulating levels of Hcy and NGAL can reflect the de-velopment of chronic heart failure concurrence insufficient renal function .
