SEDATION AND HYPNOSIS EFFECT OF JIAOTAI PILLS ON RAT INSOMNIA IN PCPA RAT MODEL
10.3969/j.issn.1671-332X.2015.07.013
- VernacularTitle:交泰丸对 PCPA 大鼠失眠模型镇静催眠的效果研究
- Author:
Xiaoying LIAO
;
Hui ZHOU
;
Shijian QUAN
- Publication Type:Journal Article
- Keywords:
Jiaotai Pill;
high-performance liquid chromatography method for detection;
pharmacodynamic study
- From:
Modern Hospital
2015;(7):35-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the sedative and hypnotic effect of Jiaotai Pills on insomnia in PCPA rat model .Methods The PCPA ( PCPA acid) rats insomnia model was established, and the rats were divided into the model group, high, middle and low dosage of Jiaotai Pills group, and diazepam positive control group.The high performance liquid detective method was adopted to observe the effect of Jiaotai Pills on rat insomnia and hypothalamus neurotransmitters 5-HT and GABA.Results Compared with the model group, there existed significant difference in the insomnia state of rats and the central neurotransmitters 5 -HT in the high and middle dosages of Jiaotai Pill group and diazepam group.However, in the comparison of the high and middle dosages of Jiaotai Pill group and the model group, there was no significant difference in GABA in the central nervous system .Conclusion Jiaotai Pills has sedative and hypnotic efficacy.Its mechanism may be related to the effects of central neurotransmitter 5 -HT.Its relationship with GABA in the central nervous system is not obvious.The research has significant influence on the further development of Jiaotai Pills.
