CURATIVE EFFECT OF COMBINATION OF DRUGS IN THE TREATMENT OF SALT-SEN-SITIVE HYPERTENSION
10.3969/j.issn.1671-332X.2015.07.027
- VernacularTitle:联合药物治疗盐敏感性高血压的疗效分析
- Author:
Yingchao LUO
;
Jinqiang ZHANG
;
Youliang CHEN
- Publication Type:Journal Article
- Keywords:
Primay hypertension;
Salt sensitive;
Antihypertensive drug;
Drug combination
- From:
Modern Hospital
2015;(7):66-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the clinical effect and influence combination of drugs on the functions of target organs in the patients with salt-sensitive hypertension.Methods 125 patients with salt-sensitive hypertension, their clinical data retrospec-tively analyzed, divided into two groups, treated with coaprovel and felodipine combined with irbesartan respectively for 8 weeks.The levels of left ventricular mass index (LVMI), fasting blood glucose (FBG), triglyceride (TC), total cholesterol (TC) and blood 2-microglobulin (2-MG) during the treatment were then observed.Results The amplitude of blood pressure was significantly lower in the coaprovel group after 4 weeks and 8 weeks of treatment in the patients with salt -sensitive hypertension.However, there was no statistical difference of effectiveness between the coaprovel group ( 81.0%) and the felodipine combined with irbesartan group (83.9%).The decrease range of LVMI showed significantly better results in the coaprovel group (28.9 ±7.3).Moreover, there was no statistical difference in other indexes between two groups or before and after treatment .Conclusion Coaprovel has a similar cura-tive effect with felodipine combined with irbesartan in the treatment of patients with salt -sensitive hypertension.It has more signifi-cant protective effect for heart damage .
