Progress of c-Met signaling pathways in a variety of malignant tumors
10.11904/j.issn.1002-3070.2015.02.016
- VernacularTitle:c －Met 信号通路在多种恶性肿瘤中的研究进展
- Author:
Yujiao FU
;
Zhiwei LI
;
Yanqiao ZHANG
- Publication Type:Journal Article
- Keywords:
HGF;
c-Met;
Inhibitor of c-Met;
Solid tumor
- From:
Practical Oncology Journal
2015;(2):167-172
- CountryChina
- Language:Chinese
-
Abstract:
In recent years ,the treatment of malignant tumor has entered the era of individualization and molecular target .Therefore,research and development of new therapeutic targets for cancer patients has become a top priority.A large number of clinical and experimental research found that HGF is produced by mesenchymal cells,which is combined with epithelial cells of specific receptors c -Met to activate the receptor tyrosine activity , promoting the growth ,migration and morphological change of a variety of cell ,and then to promote the tumor inva-sion,metastasis and angiogenesis .HGF and its receptor c-Met play an important role in the progression of thy-roid cancer,breast cancer,lung cancer,head and neck squamous cell carcinomas ,central nervous system tumors and digestive system tumors .HGF/c-Met signaling pathway ,as a new targets for a variety of solid tumors ,is con-sidered to be the most promising therapeutic targets in recent years ,it has also become one of the hot spots of cur-rent research.This article will mainly discuss HGF and c -Met receptor′s structure,function,activation mecha-nism and research progress in a variety of malignant tumor .A large number of clinical and experimental research found that HGF is produced by mesenchymal cells and epithelial cells with a specific receptor combination c -Met and activates the receptor tyrosine activity .
