Propress of epigenetics mechanism during tumor development---DNA methylation
10.11904/j.issn.1002-3070.2015.02.017
- VernacularTitle:肿瘤发生过程中表观遗传学机制－DNA甲基化的研究进展
- Author:
Huizi YIN
;
Ming SHAN
;
Zilong YOU
;
Da PANG
- Publication Type:Journal Article
- Keywords:
DNA methylation;
Tumor;
Mechanism;
Detecting technology;
Clinical applications
- From:
Practical Oncology Journal
2015;(2):173-177
- CountryChina
- Language:Chinese
-
Abstract:
As a heritable regulation , epigenetics can regulate gene expression by other ways without changing the DNA sequence ,and change cell or individual phenotypes .DNA methylation is an issue in the field of epigenetics research.Recently,many studies have been demonstrated that the methylation of repetitive DNA ,spe-cific gene and CpG island and loss of imprinting play an important role in tumor occurrence .As the development of technological approaches to DNA methylation ,we have a more comprehensive understanding on methylation pat-terns.As specific markers,abnormal methylation sites in the genome can be used in the diagnosis ,treatment and prognosis predictor of disease .For tumor development caused by DNA methylation ,the application of demethylat-ing drugs have achieved good effect in clinical treatment .
