Research progress on tumor-associated macrophage in gastric cancer
10.3969/j.issn.1002-3070.2014.03.017
- VernacularTitle:肿瘤相关巨噬细胞在胃癌中的研究进展
- Author:
Yu HE
;
Ou JIANG
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Tumor -associated macrophage;
Coagulation factors;
M1 phenotype;
M2 phenotype
- From:
Practical Oncology Journal
2014;(3):272-275
- CountryChina
- Language:Chinese
-
Abstract:
It has been confirmed that tumor invasion and metastasis is not only dependent on the charac -teristics of the tumor ,but also dependent on the tumor microenvironment .Tumor-associated macrophage ( TAM) , which constitutes a large number of the tumor -infiltrating immune cells,is stimulated into M1 macrophage and M2 macrophage by different signals in the tumor microenvironment .Whereas the vast majority of studies with nu-merous tumor types show that the presence of M 2 phenotypes in the tumor microenvironment is associated with a worse prognosis ,most studies in gastric cancer also claim the same results .Hypoxia and coagulation factors may both contribute to it .It has identified that the function of TAM could be changed with their location of tumor ,but it has nothing to do with cell differentiation and cell type of gastric cancer .In this review,we summarize the differ-ent and controversial effects of TAM in gastric cancer .
