The research on nerve growth factor in chemotherapy-induced peripheral neuropathy
10.3969/j.issn.1002-3070.2014.03.015
- VernacularTitle:神经生长因子与化疗所致周围神经病变的相关性研究
- Author:
Bin HAN
;
Jiege HUO
- Publication Type:Journal Article
- Keywords:
Nerve growth factor;
Chemotherapy;
Peripheral neuropathy;
Review
- From:
Practical Oncology Journal
2014;(3):263-267
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy -induced peripheral neuropathy ( CIPN ) is one of the most common adverse effects in chemotherapy .The mechanism of CIPN has always been attracting researchers′attention.Recently,the intimate relationship between nerve growth factor and CIPN is one of the most hot topics .NGF protects neurons from damage of chemotherapy drugs through inhibiting apoptotsis and other pathway to relieve the neurotoxicity . However ,there are still many problems in the clinical application of exogenous NGF .To improve the mechanism of NGF in the development and application approach of CIPN ,treatment of chemotherapy -induced peripheral neu-rotoxicity is of great significance .
