HE4 expression in serous ovarian cancer tissues and its relationship with clinicopathological features
10.3969/j.issn.1002-3070.2014.03.008
- VernacularTitle:H E4在浆液性卵巢癌组织中的表达及与临床病理因素的关系
- Author:
Cong LI
;
Xiaolin WU
;
Guodong YAO
;
Huilei QIU
;
Jingbo ZHANG
;
Hongtao SONG
;
Jingshu GENG
- Publication Type:Journal Article
- Keywords:
HE4;
Serous ovarian cancer;
Immunohistochemisrtry;
CA125
- From:
Practical Oncology Journal
2014;(3):228-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression level of human epididymis protein 4 ( HE4 ) in se-rous ovarian cancer tissues and its relationship with clinicopathological features .Methods The expression level of HE4 in 140 serous ovarian cancer patients and its relationship with clinicopathological features were detected by immunohistochemistry.To compare the correlation between HE4 and CA125, the histological expressionOf CA125 was also detected by IHC .Results the positive expression rate of HE 4 and CA125 in moderately and poorly differentiated serous ovarian cancer tissues were respectively 89.76%and 81.89%;the positive expression rate in well differentiated group were respectively 46.61% and 15.38%,in the advanced stages were 92.44%and 83.19%,in the early stages were 47.62%and 33.33%.the positive expression rate of lymphatic metastasis were 95.65%and 84.35%,without lymphatic metastasis were 40.00%and 36.00%,the positive expression rate of peritoneal implantation were 90.00% and 87.27%, without peritoneal implantation were 70.00% and 33.33%;the positive expression rate of ascites were 89.76% and 79.53%,without ascites were 46.15% and 38.46%.Besides,the positive expression rates of HE4 and CA125 were 86%and 76%,the differences were sta-tistically significant.Both the positive expression in ovarian cancer are correlated positively (P<0.05).The ex-pression of HE4 and CA125 has nothing with the occurrence of pausimenia and the number of parity in patients with ovarian cancer(P>0.05).Conclusion The expression of HE4 in serous ovarian cancer is related with FI-GO stages,the degree of tumor differentiation ,lymph node metastasis and ascites .
