Research progress of Hedgehog-Gli signaling pathway in lung cancer
10.11904/j.issn.1002-3070.2015.02.018
- VernacularTitle:Hedgehog －Gli 信号通路在肺癌中的研究进展
- Author:
Lei WANG
;
Gongyan CHEN
- Publication Type:Journal Article
- Keywords:
Hedgehog;
Gli;
Non-small cell lung cancer;
Small cell lung cancer;
EGFR-TKI resistance
- From:
Practical Oncology Journal
2015;(2):178-182
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog-Gli signaling pathway involves in vertebrate embryonic development ,tissue differ-entiation,organogenesis,and plays an important role in homeostasis ,the maintenance of stem cell function ,regula-tion of epithelial mesenchymal transition .Hedgehog-Gli signaling pathway activation correlates with a variety of tumor development ,invasion,apoptosis and drug resistance .This review seeks to clarify the composition of Hedge-hog-Gli signaling pathway ,mechanism of action ,the role of Hedgehog-Gli signaling pathway in lung cancer de-velopment and function of lung cell of the EGFR -TKI resistance .
