Clinical pathology significance of Hepsin in breast infiltrating ductal carcinoma
10.3969/j.issn.1002-3070.2014.03.005
- VernacularTitle:乳腺浸润性导管癌中 Hepsin 的表达及临床病理意义
- Author:
Chuan HE
;
Li TAO
;
Gen SUN
;
Guoqiang ZHANG
- Publication Type:Journal Article
- Keywords:
Hepsin;
Infiltrating ductal carcinoma;
Immunohistochemistry
- From:
Practical Oncology Journal
2014;(3):213-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of hepsin and its role in the pathogenesis of breast infiltrating ductal cancer ( BIDC) .Methods The expression level of hepsin was examined by immunobloting and immunohistochemistry in breast tissue samples from 8 healthy controls and 139 patients with BIDC,respectively. The correlation between hepsin level and its significance in clinical pathology of BIDC was assessed by statistical analysis.Results High level of hepsin was detected in nearly 70.5 percent of BIDC samples(98 out of 139)by immunobloting and immunohistochemistry , while the level of hepsin was relatively low or hardly detectable in healthy controls.In addition,there was a significant correlation between hepsin level and clinical stages as well as the level of histological differentiation of BIDC .Conclusion Increased expression of hepsin might play an impor-tant role in pathogenesis and progression of BIDC .The level of hepsin is positively correlated to clinical stages of BIDC,but negatively correlated with the level of histological differentiation of BIDC .
