Expression and clinical significance of RegⅣ,EGFR and PI3K proteins in human gastric adenocarcinoma
10.3969/j.issn.1002-3070.2014.03.010
- VernacularTitle:RegⅣ、EGFR、PI3K蛋白在胃腺癌中的表达及意义
- Author:
Xianfeng QIN
;
Huiming ZHU
;
Haijun ZUO
;
Yujie LIU
;
Changwei CHEN
- Publication Type:Journal Article
- Keywords:
Regenerating gene typeⅣ( RegⅣ);
Gastric adenocarcinoma;
Epidermal growth factor recep-tor(EGFR);
Phosphatidylinositol -3-kinase(PI3K);
Immunohistochemistry
- From:
Practical Oncology Journal
2014;(3):239-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of RegⅣand EGFR,PI3K proteins in gastric adenocarcinoma .Methods S-P immunohistochemistry was used to detect the expression of RegⅣand EGFR,PI3K proteins in pathological tissues of 73 cases with gastric adenocarcinoma and tumor -adja-cent normal gastric tissues .Results The positive expression rates of RegⅣand EGFR,PI3K proteins in 73 cases with gastric adenocarcinoma tissue were 50.7%(37/73),56.2%(41/73) and 69.9%(51/73) respectively, which were significantly different from the positive expression rates of tumor -adjacent normal gastric tissues ,be-ing 20.5%(15/73),19.2%(14/73),and 21.9%(16/73),respectively(P<0.05).The expression of RegⅣprotein was significantly correlated to differentiation degree ( P<0.05 ) and the expression of EGFR protein was significantly correlated to infiltrative depth,TNM stage,and lymph node metastasis(P<0.05).The expression of PI3K protein was significantly correlated to differentiation degree ,infiltrative depth,TNM stage and lymph node metastasis(P<0.05).There was positive correlation between the expressions of RegⅣ/EGFR,RegⅣ/PI3K and EGFR/PI3K proteins in gastric adenocarcinoma and the values of Spearman coefficient correlation were 0.325, 0.403 and 0.384,respectively(P<0.05).Conclusion RegⅣmay play an important role in gastric adenocarci-noma genesis and progression by activating EGFR /PI3K/Akt signaling pathway .
