The correlation of miR-106a expression with clinical characteristics and prognosis of colon cancer
10.3969/j.issn.1002-3070.2014.03.011
- VernacularTitle:结肠癌中miR-106a的表达与临床特征和预后相关性
- Author:
Yingying FANG
;
Yang PAN
;
Caihong SONG
;
Ying LI
;
Qiang LI
- Publication Type:Journal Article
- Keywords:
Colon cancer;
miR-106 a;
Prognosis;
Clinical characteristics
- From:
Practical Oncology Journal
2014;(3):245-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the correlations of miR -106 a expression with clinical features of pa-tients with colon cancer ,and to explore the significance of miR -106 a as a prognostic factor .Methods One hun-dred and five patients with primary colon cancer were retrospectively enrolled in this study including their clinical information and slices of FFPE.miR-106a expression was detected by qRT -PCR,and analyzed the correlation between the level of miR -106a and clinical features and survival .Results The level of miR -106a in tumor tissue was higher than adjacent normal tissue (1.142 vs.0.685,P<0.001).miR-106a was correlated with TNM stage and lymphnode metastasis .The higher miR -106a expression,the poorer survival patients were .The hazard risk was increased 3.390 folds(95%CI for HR:1.028 ~11.178)when compared high expression group with the low.Conclusion The aberrant expression of miR -106a may be associated with colon cancer .It will po-tentially be a therapeutic target and prognostic factors .
