Survivin overexpression promotes proliferation of laryngeal carcinoma
10.3969/j.issn.1002-3070.2014.03.012
- VernacularTitle:Survivin 在喉癌中的表达及与细胞增殖的相关性研究
- Author:
Xiaoling QIN
;
Zhilong YU
;
Yuling JIA
;
Yingna BAO
- Publication Type:Journal Article
- Keywords:
Laryngeal carcinoma;
Survivin;
Cell proliferation;
DNA content
- From:Practical Oncology Journal
2014;(3):250-254
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study is to investigate the expression of Survivin in laryngeal car-cinoma and to elucidate the relationship between cell proliferation and the expression of Survivin .Methods The expression and DNA quantification of Survivin in 63 cases of laryngeal carcinoma and 15 cases of normal laryngeal tissues were detected by immunohistochemical staining ( SP) and flow cytometry .Results Forty-five sections of laryngeal carcinoma were positive for survivin as determined by immunohistochemical staining ,but Survivin was undetected in normal laryngeal tissues .The intensity of Survivin expression was significantly increased with tumor differentiation and lymph node metastasis (P<0.05),and was negatively correlated with age ,gender and clinical stage of patients(P>0.05).High DNA index(DI)and proliferation index(PI)were detected in laryngeal carcino-ma(P<0.05),and PI was positively correlated with expression of Survivin (P<0.05).Conclusion Survivin overexpression triggers laryngeal carcinoma cell hyperproliferation ,especially in development of laryngeal carcino-ma.These data identify Survivin as an important target in laryngeal carcinoma and provide a translational pathway for developing new therapies against this target .
