The role of tumor associated macrophages in tumor progression
10.3969/j.issn.1002-3070.2014.03.014
- VernacularTitle:肿瘤相关巨噬细胞与肿瘤关系的研究进展
- Author:
Hongmei WU
;
Lei QI
;
Lihui SHAN
;
Cuicui CHAI
;
Lifeng WANG
- Publication Type:Journal Article
- Keywords:
Tumor associated macrophages;
Angiogenesis;
Cancer stem cells;
Tumor microenvironment
- From:
Practical Oncology Journal
2014;(3):258-262
- CountryChina
- Language:Chinese
-
Abstract:
Tumor associate macrophages ( TAMs) play a significant role in the interaction of tumor inflam-mative microenvironment and tumor cells .TAMs originate from monocytic precursors ,recruiting into tumor tissue by colony stimulating factor ( CSF) .This review summarized that TAMs promote tumor progression and metastasis though angiogenesis ,lymphogenesis , immunosuppression , matrix remodeling and affecting cancer stem cells .The article pointed that targeting TAMs is a new strategy for future tumor therapy .
