The research progress of survivin targeted therapy in cancer research
10.3969/j.issn.1002-3070.2014.02.015
- VernacularTitle:Survivin 靶向治疗在肿瘤中的研究进展
- Author:
Wei DENG
;
Xingwang SUN
- Publication Type:Journal Article
- Keywords:
Survivn;
Cancer;
Therapy
- From:
Practical Oncology Journal
2014;(2):165-169
- CountryChina
- Language:Chinese
-
Abstract:
Survivin,the smallest and structurally unique member of the inhibitor of apoptosis protein (IAP)family,is highly expressed during fetal development and rarely expressed in self -renewable healthy adult tissues.Moreover,it exists in most malignant tissues .Survivin is described as a bifunctional protein involving in the regulation of cell proliferation and apoptosis in normal and cancer cells .Due to its structural and functional distinctiveness ,survivin is currently attracting considerable attention as a new target for cancer molecular targeted therapy.Strategies to targeting Survivin include antisense oligonucletides ,ribozymes,siRNA,dominant negative mutants,small molecule antagonists and immunotherapy .
